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Provides organ protection and anti-ulcer effects

GSH depletion-dependent cell death was prevented by selective ferroptosis inhibitors (8 M Fer-1 and 600 nM Lip-1), iron chelator DFO (80 M), as well as autophagic inhibitors Baf-A1 (75 nM) and 3-MA (10 mM)

Phosphorylated -catenin is released from DCs and bound by Trcp-1 (also known as -Trap) for ubiquitination and subsequent degradation

Extensively studied for copper-dependent signaling, ECM remodeling, and gene expression profiling in vitro

Although impressive, it is important to recognize that this was a small study

Furthermore, the high heterogeneity of tumors means that different tumor cells exhibit varying degrees of dependence on Gln, resulting in inconsistent sensitivity to these imaging agents