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The 2024 review in Pharmaceuticals concluded that "clinical trial evidence for L-arginine or L-Citrulline in chronic blood pressure reduction in the general population requires an examination of trial designs, as not all translational studies may have influenced vascular reactivity." Reasonable medical professionals reviewing this evidence category would reach different conclusions about the appropriate role for these supplements - that's an honest characterization of where the science stands

Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis

Retrieved 16 May 2020

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Sosa-Eroza E, Espinosa-Crdenas E

It most commonly strikes women and adults over age 40