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Natural Product Reports , 38 (1), 83102

Urolithin A is a metabolite derived from ellagitannins found in foods such as pomegranates, whereas spermidine is a naturally occurring polyamine found in various plant-based foods such as wheat germ and soyabeans

Neuropathological investigations in the substantia nigra pars compacta of Parkinsons disease patients demonstrate that deficient PGC-1 expression compromises mitochondrial biogenesis and disrupts the coordinated transcriptional activation of antioxidant stress-responsive gene networks, thereby precipitating dopaminergic neuronal degeneration (Piccinin et al., 2021)

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