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Erastin can directly bind to VDAC 2 and alter mitochondrial membrane permeability, thereby inducing nonapoptotic cell death [48]

Sharma A, Michelle L, Juhasz M, Muller Ramos P, Atanaskova Mesinkovska N (2020) Low-dose oral minoxidil as treatment for non-scarring alopecia: a systematic review

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A recent study has shown that, in ARPE-19 cells and DR mouse models, it was found that TERF1 Interacting Nuclear Factor 2 (TIN2) inhibits mitophagy by promoting mTOR pathway activity, thereby inducing the aging of RPE cells under high glucose conditions