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Characterization of CAA0225, a novel inhibitor specific for cathepsin L, as a probe for autophagic proteolysis

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The results indicate a protective role of GSTP1 by enhancing GSH-conjugation, which might lead to a reduced protein modification, and suggest a second protective role by interfering with the unfolded protein response, thereby preventing apoptosis

All documented observations remain confined to investigational, laboratory-based examination and do not extend beyond structured research frameworks

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Glutathione acts as the primary defense system, stepping in to stabilize these molecules before they can do harm