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The content of Fe 2+ is strictly regulated, and when its level is out of balance, excess ferrous will provide electron-promoting lipid peroxidation via Fenton reaction, resulting in an increased production of ROS and inducing ferroptosis (Kajarabille and Latunde-Dada 2019

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Sakamoto K., Iwasaki K., Sugiyama H., Tsuji Y., Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications.Mol

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