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[,] However, the aetiology of depression remains incompletely understood

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When intestinal barrier integrity is compromised or permeability increases, LPS enters the circulation via the paracellular pathway or through lipoprotein-mediated transcellular transport

For example, a study compared the effects of administration of NAC 0.6 g + folic acid 500 g/day in a group of 80 patients with a history of RM with an aged-matched group of 86 patients treated with folic acid 500 /day alone (204)