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However, this particular dose is indicated for sleep-related pathologies such as jet-lag and works by targeting the central nervous system where canonical melatonin receptors are abundantly expressed (69)

This dual-system approach, addressing both the gut and the brain simultaneously, is something no conventional medication offers

Thiamine: Genomics, Cellular Energy, and Cognitive FunctionAlso known as vitamin B1, thiamine is essential for energy production and brain function

REDEFINE 1 (Phase 3a, NEJM 2025) Garvey et al., n=3,417, 68 weeks

Three technical replicates of 100 L culture were taken from each culture flask sample prior to quenching cells in cold methanol/water