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The disease spectrum of NAFLD includes non-alcoholic fatty liver, also known as simple fatty liver, non-alcoholic fatty hepatitis, fatty liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) ( Many preclinical studies have shown that caffeine intake alleviates NAFLD and can even prevent NAFLD in high-fat-diet (HFD)-fed mice ( / and HFD-fed WT mice

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2 Pathophysiology and molecular mechanisms of Parkinsons disease Parkinsons disease (PD) is a multifactorial neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc)

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The RMSF curves of the two conformations in mTYR are very similar (Fig