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For instance, in an investigation of atherosclerosis induced by HUA, exposure to sUA significantly heightened macrophage iron death through the NRF2/SLC7A11/Glutathione peroxidase 4 (GPX4) signaling pathway (67)

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Studies of SARS-CoV-2 have also shown that a specific region of the spike protein, known as the receptor binding domain, binds to a receptor called angiotensin-converting enzyme 2 (ACE2)