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In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone

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When combined with anti-PD-L1 immunotherapy, IR further reduces the accumulation of MDSCs in the TME, creating a more inflammatory environment and effectively reversing immunosuppression (114)

DHT binds to androgen receptors in hair follicles, triggering a miniaturization process that progressively shrinks follicles until they can no longer produce visible hair