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Meanwhile, studies have designed loaded PEI-SS-IND-MTX-MMP-9 siRNA nanoparticles for RA cartilage damage for the delivery of indindexin (IND), MTX, and MMP-9 siRNA, which significantly downregulated the expression of MMP-9 and various inflammatory factors in Raw-264.7 cells and showed anti-inflammatory activity and reversal of bone destruction in RA mice (291)
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