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GHK-Cu levels in the body decline significantly with age

However, once the benzimidazole is detached from cobalt by quaternization with methyl iodide, it is replaced by H 2 O or hydroxyl ions

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While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control