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Senescent cells accumulate with aging and after acute stresses like chemotherapy, secreting inflammatory mediators collectively termed the senescence-associated secretory phenotype (SASP)

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A sulfate deprivation favors APS reduction for promoting cysteine, methionine, and glutathione synthesis whereas the presence of reduced sulfur sources represses APS reduction in the favor of APS phosphorylation (Takahashi et al., 1997

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