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Additionally, there may have been a stimulation of collagen production, which is vital for the skin's structural integrity, enhanced activity of fibroblastscells crucial for wound recovery and an increase in mast cell activation, which plays a role in the inflammatory responses

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However, human clinical safety data remain extremely limited

Clin Endocrinol 72:334341 Mracek T, Gao D, Tzanavari T, Bao Y, Xiao X, Stocker C, Trayhurn P, Bing C (2010) Downregulation of zinc-a2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-a in adipocytes