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All protein and ligand atoms were treated as anisotropic in B -factor refinement if the structure was at least 1.4 in resolution, as for the papainE-64d and papain(2 S ,3 S )- t -ES- a9 - b7 structures, although solvent atoms remained isotropic

doi: 10.4995/wrs.2015.3644 165

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doi: 10.5812/jjm.14814 317 ShuCGeLLiZChenBLiaoSLuLet al