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En l'absence de rponse thrapeutique lors de l'administration de vitamine B12 au cours d'anmies mgaloblastiques, le diagnostic d'un dficit du mtabolisme de l'acide folique doit tre considr

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Recovery-enhancing agents such as epithalon, delta sleep-inducing peptide, and pinealon target circadian and mitochondrial regulators, and neuroactive peptides like selank, semax, and dihexa enhance brain-derived neurotrophic factor and HGF/c-Met pathways critical to neuroplasticity

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Elevation in homocysteine is expected with cobalamin deficiency due to reduced methionine synthase activity even in the face of extreme cobalamin deficiency