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Many studies have confirmed oxidant-antioxidant imbalance in migraine, including NO, malondialdehyde (MDA), thiobarbituric acid reactive substances, thiol, catalase, superoxide dismutase, and glutathione imbalances (141, 142)

TDP-43-induced inflammatory responses in microglia were attenuated when treated with an IL-6 trans-signaling inhibitor in vitro , suggesting that IL-6 trans-signaling may act as a potential driver of inflammation in ALS pathogenesis (Risby-Jones et al., 2025)

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Clinical journal of the American Society of Nephrology : CJASN