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for example, in patients with gliomas, methylation of the promoter of the DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is a problem in cancer therapy with alkylating agents [139] (Table 2)

Of the six who agreed to treatment, all responded to B12 treatment by injection with varying degrees of success

398(10317):21602172., Pivotal Phase 2 monotherapy

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Many people have trouble with nutrient absorptionfrom supplements or fooddue to the presence of intestinal inflammation, poor gut health, or a deficiency of intrinsic factorsglycoprotein produced in the stomach thats essential for B12 absorption

Accordingly, the ER-mitochondria axis-positioned at the core of cellular processes implicated in neurodegenerative diseases-has been prioritised in this review as the principal framework for examining organellar crosstalk