SLC31A1 is significantly correlated with diverse immune cell infiltrations, immune cell biomarkers, and immune checkpoints in breast cancer and is regulated by the LINC01640/miR-204-5p/SLC31A1 axis, which may be central to copper-induced cell death in breast cancer, suggesting that SLC31A1 may serve as a potential target for adjuvant immunotherapy [103]
Research utilizing the Broad Institute's Connectivity Map indicates it influences the expression of over 4,000 genes (~31% of the human genome), shifting gene signatures from a pathological state back to a healthier, regenerative baseline
These compounds also inhibite glucokinase (GCK), pyruvate kinase (PK), and citrate synthase (CS) in the liver, further verifying the potential role of Scrophulariae Radix in regulating glucose metabolism and inhibiting excessive metabolism (103)
10.1016/j.ejca.2012.08.019 6
Excitatory amino acid carrier 1 (EAAC1) is a key protein responsible for the absorption of cysteine into neurons in rats, while in humans, this role is fulfilled by EAAT3
How Does Glutathione Work In the Body
