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Lyme disease most often presents locally with a migrating skin rash called erythema migrans (EM) but, if left untreated, can give rise to inflammatory complications in the joints (3), heart (4), or nervous system (5)

The primary endpoint of the study is the relative change in body weight from baseline to week 68

However, it may also be an indication of other factors or conditions, such as oxidative stress

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 20% by weight of the poloxamer

This under-representation renders the process of tuning warhead reactivity largely empirical

Consequently, this modification leads to the separation of the subunits or reconfiguration of the heterotrimers, enabling G and G to interact with and regulate a diverse array of effector molecules, which is continuously expanding