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4 Other trials on NAD+ for addiction typically had patients use 500-1000mg of NAD+ in 300mL of normal saline typically with a loading period of daily dosing for four days, followed by a taper period of twice weekly dosing for a month, and finally reducing to just twice monthly dosing until resolution of addiction

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This is because pernicious anemia is not simply a vitamin B12 deficiency but an autoimmune condition that prevents the body from absorbing vitamin B12 in the gut, even when it is available

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