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FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway

Gravina AG, Pellegrino R, Palladino G, Coppola A, Brandimarte G, Tuccillo C, Ciardiello F, Romano M, Federico A

511 It facilitates the ubiquitination and degradation of IRE1 in FLS from mice with collagen-induced arthritis (CIA), protecting synovial cells from ER stress-induced apoptosis

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Besides, the concentration of 17a-estradiol, rather than 17-estradiol that was well-investigated in Caucasian populations and in animal models of MS (111113, 126), was altered significantly in Chinese patients with MS