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doi: 10.1038/srep32206 (2016)

Most patients exhibit a decreased and disorganized background rhythm, along with focal or multifocal sharp waves during the interictal period ( MT-ND1 mutation demonstrated decreased background activity, multifocal epileptic discharges, and significant irregularity ( MRI findings in LS often help elucidate the underlying etiology, with classic abnormalities involving the basal ganglia, particularly the bilateral putamen, periaqueductal gray, and brainstem ( SURF-1 mutations, symmetrical involvement of the bilateral brainstem and subthalamic nuclei is common, and some patients exhibit basal ganglia abnormalities

Implications of NAD+ boosters in translational medicine - Kang - 2020 - European Journal of Clinical Investigation - Wiley Online Library n.d

These are sulfur-containing molecules that catalyze the oxidative decarboxylation of alpha-keto acids, such as pyruvate and alphaketoglutarate, in the Krebs cycle

[DOI] [PubMed] [Google Scholar] 19.Masuda Y, Tanaka T, Inomata N, et al

Long-term risks unknown: Chronic use could have consequences that have not yet been documented