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Evidence summary by indication Oxaliplatin-induced peripheral neuropathy prevention (chemotherapy) Design and dose: Randomized, double-blind, placebo-controlled trial in advanced colorectal cancer

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In amphetamine-induced mania animal models, pharmacologic antagonism or genetic deletion of P2X7 appears to be behaviorally therapeutic, with concomitant reductions in proinflammatory cytokine release and lipid peroxidation [1]

Kumar TR, Wiseman AL, Kala G, Kala SV, Matzuk MM, Lieberman MW: Reproductive defects in gamma-glutamyl transpeptidase-deficient mice

These taxa form a pathogenic synergistic network: Prevotella provides metabolic substrates through carbohydrate degradation, Fusobacterium enhances biofilm structural stability to facilitate persistent colonization, and Porphyromonas secretes virulence factors that damage periodontal tissues and suppress host immunity