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Moreover several GST polymorphisms, ranging from null phenotypes to point mutations, were detected in members of the family and found to correlate with the onset of neuro-degenerative diseases

Peer review Peer review information Nature Catalysis thanks Mattheos Koffas, Bengt Mannervik, Boas Pucker, Dingguo Xu and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

PMID: 18796312

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In particular, reduced GST activity as compared to control subjects was described in all brain areas and ventricular CSF in postmortem AD patients, suggesting a role of these enzymes in the pathogenesis of the disease 51