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It's possible that lower doses of each medication might be sufficient when used together, potentially mitigating some of the side effects while maintaining efficacy

Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway

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Psychiatry Res 218: 5460, 2014

Induced release of membrane vesicles from rat adipocytes containing glycosylphosphatidylinositol-anchored microdomain and lipid droplet signalling proteins