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The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO), registration number: CRD42024554513 (Available from) (NIHR, 2025)
Its cellular-level mechanism appeals to those wanting to optimize metabolic function rather than override it
Medical Conditions Requiring Caution: Individuals with heart conditions Those with liver or kidney disease People with metabolic disorders Patients with Leber's disease (affecting the optic nerve) Those with low potassium levels (hypokalemia) [12] Pregnancy and breastfeeding present special considerations for MIC B12 treatment
Whilst the quantities are minuscule and generally harmless, individuals with impaired kidney function may theoretically have reduced capacity to eliminate this cyanide with very high doses over extended periods, though this remains largely theoretical at normal supplemental doses
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