Researchers investigate its role as a cofactor for glutathione peroxidase and S-transferase enzymes, and examine its involvement in xenobiotic metabolism and heavy metal chelation pathways in cell cultures
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Unlike other forms of regulated cell death, cuproptosis is characterized by the direct binding of reduced copper (Cu + ) to lipoylated proteins of the tricarboxylic acid (TCA) cycle, most notably dihydrolipoamide S-acetyltransferase (DLAT), together with destabilization of iron-sulfur (Fe-S) cluster proteins such as succinate dehydrogenase complex ironsulfur subunit B (SDHB) 164
Elevation of intracellular glutathione content associated with mitogenic stimulation of quiescent fibroblasts
Additionally, some medications can affect glutathione levels
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