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The discovery of the Innate Repair Receptor turned our understanding of inflammation on its head

Interestingly, 2 unbiased drug repurposing screens of SCA3 cellular and animal models identified compounds that modulated neurotransmission as suppressors of mutant ATXN3 pathogenesis [164, 165]

For one, it makes a robust clinical trial logistically tricky, said Christopher Milne, past director of research at the Tufts Center for the Study of Drug Development

There is no consistent evidence suggesting that B12 injections worsen depressive symptoms

Anyone considering treatment should discuss it with a healthcare professional before receiving a B12 deficiency injection

For those facing long domestic wait times, high private evaluation costs, or limited access to advanced treatments, it presents a genuinely compelling alternative