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The critical role of Gpx4 is underscored by the fact that whereas Gpx1-knockout mice are fully viable, Gpx4-knockout animals demonstrate embryonic lethality, and Gpx4 +/ cell lines are markedly sensitive to inducers of oxidative stress, including -irradiation, tert -butyl-hydroperoxide, and hydrogen peroxide, as compared with cell lines derived from wild-type control littermates (147)

Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators

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Recent studies have demonstrated that altering bacterial metabolic states can restore the efficacy of antibiotics in drug-resistant strains (Zhao et al., 2021

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