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terminal half-life 20-50 minutes) with a steady-state volume approximating total extracellular fluid, findings that justify loading schedules followed by less frequent injections once tissue stores exceed 2 mg

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Cyanocobalamin is also contraindicated in patients with cobalt hypersensitivity because cyanocobalamin contains cobalt

These include drugs affecting blood cell production (chloramphenicol, anticancer or HIV drugs) and other vitamin and mineral supplements (especially folic acid)

Nature Medicine 21(8):887-894