Patch-test on a small area before first use, especially if you have sensitive skin
dosing errors can increase the risk of severe gastrointestinal effects, including nausea, vomiting, diarrhea, and potentially dangerous dehydration
As for depression specifically In addition, the discovery that antagonists of the N-methyl-D-aspartate (NMDA) receptor, notably ketamine, produce rapid improvement in depressive symptoms (within hours), even in TRD patients, has shifted efforts towards novel agents targeting the glutamatergic system This is the future folks
American Journal of Rhinology & Allergy
Activation of alpha-2 receptors inhibits adenylate cyclase, and lowers intracellular cAMP, which reduces aqueous humour production by the ciliary body
5 , ra42 (2012)