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While in vitro equilibrations between redox couples such as roGFP2 and GSH/GSSG require minutes or even hours to reach a thermodynamic endpoint (G = 0), enzyme-catalyzed thiol-disulfide exchange reactions usually occur very rapidly and either maintain or reach a steady state (G 0) 7,31,32,60,63,67,78,79
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In HIV-associated lipodystrophy, daily tesamorelin significantly reduces visceral adipose tissue and improves lipid profiles over 612 months [3] [4]
