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Statistical Analysis To assess the performance of the model-informed precision dosing software as compared to other cohorts the ratio of individual AUC obs to the predefined individual AUC target was calculated for both PK1 AUC obs /AUC target and the entire course of therapy defined by cAUC obs /cAUC target

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It plays an important role in cellular energy production and the maintenance of keratin infrastructure

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These processes are essential for human brain development because they represent a quality control system that prevents brain contamination with the toxic products of damaged molecules and cellular structures [243]