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However, since in vitro and in vivo systems are very different, this hypothesis needs to be examined in the animal

doi:10.1016/S0014-2999(99)00486-0

In another study, response to escitalopram was associated with higher plasma baseline 5-HT levels, lower baseline KYN/TRP and QA/TRP ratios, and, among remitters, a treatment-related increase in the KYNA/3-HK ratio [193]