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This increased permeability allows lipopolysaccharides (LPS), food antigens, and microbial byproducts (PAMPs) to translocate into circulation, triggering systemic immune activation and placing further burden on mast cells 18

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Stacking these compounds in body recomposition protocols makes mechanistic sense: AMPK drives metabolic substrate utilization, and AHK-Cu provides the structural support for the lean tissue you're building or preserving