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A randomized, double-blind, placebo-controlled trial in 88 patients with sepsis and elevated blood concentrations of lactate reported that intravenous thiamin (200 mg twice daily for seven days or until discharge from the hospital) did not decrease lactate concentrations at 24 hours post initiation of treatment the primary endpoint of the trial (104)

902 Due to the increased demand for iron in osteoclast development, TFR1-mediated iron uptake promotes osteoclast differentiation and bone resorption activity

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Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

Vitamin A controls neuronal differentiation and neural tube formation [138]

Specifically, 16 out of 28 proteins were classified as part of the ER in the GO database