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(2012) 2:e134

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doi: 10.1038/s42003-025-08183-9, 16 ChatterjeeP.PedriniS.DoeckeJ

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1 Introduction Pattern formation in multicellular organisms involves the differential specification of cell fate by a number of highly conserved signaling pathways, including the Hedgehog (Hh) pathway ( via extracellular Hh diffusion to target cells [as recently discussed in ( Drosophila melanogaster wing disc, would cause morphogen diffusion off the plane of the epithelial cell layer into the fluid-filled compartment