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2C) [24, 26]

Our previous work using a zebrafish model system revealed that GCGR deficiency not only induces -cell hyperplasia but also upregulates glucagon gene ( Gcg ) expression in cells 16

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93,94,95 was used for overlaying the metabolite concentration data to map changes in metabolism at different phases to a global/systems scale

36 , 38 , 39 Compared to oral administration, whereby under 10% actually enters the blood stream, 52 orobuccal administration leads to over 80% absorption directly into the systemic circulation

The estimated GSSG concentration is highly influenced by sample history and treatment