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In Class 1, HDACs 1, 2, 3, and 8 are clustered based on their similarity to yeast transcriptional regulator, reduced potassium deficiency 3 (Rpd3) (Wiech et al., 2009) while HDAC 8 is found to be expressed in smooth muscle and plays a key role in muscle contractility
More recently it has been reported that the expression level of Nogo-B is upregulated in hepatocellular carcinoma and Nogo-B deficiency suppressed the tumor growth and metastasis [221]
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