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Available studies have shown that various ALOX isoforms have distinctive catalytic capabilities, and experiments with isoform-specific Alox-KO mice demonstrated fundamentally varying biological functions for the different Alox isoforms
The gut microbiome also affects the immune system, with ALS patients showing increased Th17 immune cells and higher levels of IL-17, an inflammatory cytokine that may worsen the disease (Zang et al., 2023)
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doi: 10.1289/ehp.02110s5801 5 StepkaPVsianskyVRaudenskaMGumulecJAdamVMasarikM