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Cancer risk among patients with multiple sclerosis and their parents

Interestingly, the insulin/IGF-1 pathway displays an antagonistic pleiotropy with aging, i.e., during development insulin/IGF-1 signaling has fundamental functions in cellular differentiation and the growth of animals, whereas later in the life, it regulates metabolism but its activity clearly accelerates the aging process [1, 2]

A 2005 animal study found that CJC-1295 stimulated a 4-fold increase in GH levels when administered to male Sprague Dawley rats

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This therapy obviously needs to be more investigated to avoid side effects in normal tissues but the combination of specific senescence markers to cytotoxic drugs is a potential promising therapy