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Among these, the valine-to-isoleucine substitution (V717I) was one of the first identified mutations, playing a pivotal role in the development of the amyloid cascade hypothesis of AD pathogenesis

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Probing position N108, we found that incorporation of any other amino acid resulted in a substantially reduced formation of cyanidin ( 8 ) suggesting that the hydrogen-bond interaction of the asparagine to the flavonoid substrate is critical for dehydratase activity, while GSH-transferase activity was comparatively less affected for N108 variants comprising an alanine, histidine, tyrosine or tryptophan (Fig

(Fig.1) Figure 1

32 Enzymes play a significant role in maintaining a balance between antioxidants and free radicals by either generating or breaking down ROS