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Mechanistically, this combination therapy modulates key mediators such as thromboxane A2 (TXA2) and prostacyclin (PGI2), including their downstream effector cyclooxygenase-2 (COX-2), thereby contributing to its antithrombotic properties

FOURIER Trial: The Efficacy Benchmark The FOURIER trial (N=27,564 patients with established atherosclerotic cardiovascular disease already on statin therapy) established evolocumab's clinical profile

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Isolation of the hemopexin receptor from human placenta