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Current knowledge of PCD is largely based on hallmark signaling pathways, such as BAX-mediated mitochondrial apoptosis and GPX4-mediated ferroptosis

Mechanical stress can unfold or aggregate these structures

Carbohydrate is just as broad: kale and cake are both carbohydrates, and so is laetrile, a sugar compound from apricot pits that was sold for years as a cancer cure and released cyanide in the body

10.1046/j.0014-2956.2001.02649.x 626 UverskyV

Those decisions are shaped by sleep, stress chemistry, insulin signaling, and mitochondrial efficiency