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KPV was shown to be actively transported into colonic epithelial cells and immune cells via PepT1, where it reduced NF-kB and MAPK signaling, suppressed pro-inflammatory cytokine production, and attenuated disease severity in both DSS-induced and TNBS-induced colitis mouse models

The Biochemical Advantage The power of this combination lies in addressing multiple limiting factors in NO production simultaneously: L-citrulline elevates plasma arginine in a way that direct arginine supplementation cannot, creating a sustained supply of NO precursors

Hum Cell 1993

Available online: 12.Allocati N., Masulli M., Di Ilio C., & Federici L

The preclinical literature supports this framing

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