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And importantly, if unintended weight loss occurs in a lean patient, we stop or lower the dose

This included elevations in the levels of many essential and non-essential amino acids, including methionine and S-Adenosyl homocysteine (SAH), a metabolite in the cysteine and methionine metabolism pathway (Fig

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Taken together, these observations suggest that except in vitamin B 12 deficiency (which only responds to cyanocobalamin treatment because of the inactivation of methionine synthase), folate treatment should be the most adequate therapy to reverse hyperhomocysteinemia detected both under basal conditions and after an oral methionine load