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doi: 10.1016/j.freeradbiomed.2020.02.028

It helps regulate: blood sugar appetite digestion GLP-1 medications (like semaglutide) mimic this hormonebut in a longer-lasting, more powerful way

Have acute or chronic metabolic acidosis (including diabetic ketoacidosis)

This is because glycolic acid is notoriously irritating, thanks to its low molecular weight