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[153] reported that semaphorin 3 A (Sema3A) levels are decreased in AR patients and OVA-sensitized mice

2003 Oct 9;40(2):427-46

[PubMed] [Google Scholar] 184.Wang HH, Portincasa P, Wang DQH

Positive regulators of melanin production include endothelins, histamine, and eicosanoids, which act through cell surface receptors

There is also no global consensus on the practice of skin bleaching- controversial ingredients like mercury and IV glutathione are banned in some countries like Singapore but not all countries